The outcomes between deleted and non-deleted individuals with IAA differed significantly, in terms of the LOS (40 vs. The results revealed that the PPTD neonates had fewer days of intubation, inotrope administration, and hospital LOS when compared to the FD group. These outcomes were then compared with 40 CHOP patients with IAA but without 22q11.2DS. The examined outcomes included: timing of diagnosis age at diagnosis (days) hospital length of stay (LOS) duration of intensive care unit (ICU) stay mechanical ventilation (days) duration of inotrope administration (days) year of surgical intervention birth hospital trauma level and overall morbidity. In total, 135 patients with a diagnosis of 22q11.2DS and IAA were ascertained through the 22q and You Center at the Children's Hospital of Philadelphia (CHOP). Our goals were to determine: (1) if early diagnosis improved outcomes and (2) if patients with IAA and without 22q11.2DS had similar outcomes. those diagnosed following discharge (FD) from the newborn nursery.

In this study, we examined infants with IAA, diagnosed during pregnancy and prior to discharge (PPTD) from the birth hospital vs. However, IAA is challenging to identify prenatally, or even in the neonatal period.

Early identification and repair of IAA can prevent severe morbidity and death. IAA type B is highly correlated with 22q11.2 deletion syndrome (22q11.2DS) approximately 50% of patients with IAA type B also have 22q11.2DS (Peyvandi et al. Interruption of the aortic arch (IAA) is a rare but life-threatening congenital heart defect if not corrected in the neonatal period.

Interrupted aortic arch in newborn